Contraindicated (1)pentobarbital will lower the extent or impact of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is chargeable for the development and elimination of cariprazine's Energetic metabolites.pentobarbital will decrease the level or effect of buprenorphine subdermal implant by impacting hep